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In comparison, the first peer reviewed publication on the GSH transporter for brain targeting appeared in 2012 though a related patent was approved in 2007 [27]

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Moreover, DAQs can inhibit mitochondrial, lysosomal, autophagy and UPS functions in dopaminergic neurons [12, 60,61,62]

Neuroendocrine and Receptor Research In addition to its effects on pigmentation, Melanotan II has been investigated for its activity at other melanocortin receptor subtypes throughout the central nervous system