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The buildup of lipid peroxides plays a key role in ferroptosis, while glutathione peroxidase 4 (GPX4), an essential antioxidant enzyme, is capable of blocking, thus inhibiting ferroptosis (7)

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Moreover, as mitochondria play a central strategic role in the activation and mode of cell death, mitochondrial GSH has been shown to critically regulate the level of sensitization to secondary hits that induce mitochondrial membrane permeabilization and release of proteins confined in the intermembrane space that once in the cytosol engage the molecular machinery of cell death

Additionally, a higher proportion of type III mitochondria, characterized by irregular cristae and evident mitochondrial damage, has been observed in ectopic stromal cells compared with in eutopic cells (37)