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Beyond the earlier referenced dual treatments using MET and anti-PD-1/PD-L1 inhibitors for MET-dysregulated tumors, researchers are diligently working on creating new medications that simultaneously address c-MET and PD-1/PD-L1

The -cyano amide-based Michael acceptors have also been elegantly used by the Taunton group as warheads in small-molecule inhibitors to react with active site cysteines while being minimally affected by the high concentration of intracellular GSH due to the fast reaction kinetics and the mM of K d (refs 31, 32)