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WeekleyCMJeongGTierneyMEHossainFMawAMShanuAet alSelenite-mediated production of superoxide radical anions in A549 cancer cells is accompanied by a selective increase in SOD1 concentration, enhanced apoptosis and SeCu bonding

After the discovery of SOD as the first line of defense against ROS ( Figure 2 Apart from the SOD and catalase system, the glutathione system, which is composed of glutathione (GSH), -glutamyl cysteine synthase (GCS), GSH synthetase, glutathione peroxidase, and glutathione reductase (GSR), also plays an important role in mediating cellular redox homeostasis

10.1242/jcs.02716 125 SakuraiM.HayashiT.AbeK.AokiM.SadahiroM.TabayashiK

Biological function Oxidation mechanism of lipoic acid LA is a natural cofactor with antioxidant capacity, and scavenges reactive oxygen species (ROS) and chelates metal ions [31]