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They include hydroxyl (HO * ) and superoxide (O 2 * ) free radicals and nonradical molecules, such as hydrogen peroxide (H 2 O 2 ), which is less reactive than the majority of ROS but is able to reach any cellular compartment prior to being converted by peroxiredoxins and glutathione peroxidases into water and oxygen

This effect is consistent over time and does not plateau with prolonged use

EGCG exhibits anti-oxidation properties and therapeutic effects against AKI, CKD, kidney stone diseases, glomerulonephritis, lupus nephritis, and renal cell carcinoma ( via inhibiting Keap1 and upregulating Nrf2-ARE signaling pathway (Wang et al., 2015c