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The two main incretins are GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide, previously called gastric inhibitory polypeptide)

Based on the literature, ligands of the transferrin, insulin and leptin receptors, and low density lipoprotein receptor-related proteins (LRPs) are used to shuttle pharmaceutical agents across the BBB in preclinical studies [18, 28]

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