In a lipopolysaccharide (LPS)-induced mouse model, GLP-1 expression was reduced in peripheral blood and increased in alveolar lavage fluid and lung tissues, which was inhibited by liraglutide, a GLP-1RA, and was able to suppress LPS-induced lung injury in mice, inhibit polymorphonuclear neutrophil (PMN) extravasation, reduce the number of apoptotic cells in the lung, inhibit macrophage accumulation 48 and Liraglutide also has anti-inflammatory and airway-protective effects by modulating the PKA/NF-B signaling pathway to improve histopathological changes and airway inflammation in mice, inhibiting E-selectin overexpression and reducing mucus secretion and cupped cell proliferation
A study published in the Journal of Physiology found that 24 weeks of L-carnitine supplementation (combined with carbohydrates to enhance uptake) increased muscle carnitine content by 21% and improved exercise performance by increasing work output by 11% while reducing muscle lactate accumulation
If youre trying to lose weight, the classic advice still holds: eat a healthy diet, get plenty of exercise, get enough sleep and manage stress, Raj noted
Available at: Last updated 9/9/2010
