how are b12 injections given Shots vs. IV Infusions: What is the difference? B12 Injection Dosage and Frequency:

This "paradoxical response" (where treatment temporarily makes symptoms worse) includes: Numbness and tingling Shooting pains Joint pain Increased sensitivity Temporary inflammation (swelling and irritation) While these symptoms generally indicate that treatment is working (as nerves begin to repair themselves), they can be distressing for patients and may require additional treatment for comfort

Transit times depend on the carrier and destination

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Open questions include tissue-selective delivery, chronic dosing effects on one-carbon metabolism, and interactions with NAD precursor strategies [14,8,9]