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Description

Akin to Dpp4 / mice, mRNA expression of hepatic glucose utilization or gluconeogenic enzymes was unchanged except Gck , which trended ( P = 0.09) upward in Dpp4 hep/ mice (Figure 1K)

Pulsatile GH patterns are important for optimal receptor sensitivity and metabolic effects - continuous GH exposure can lead to receptor downregulation and may have different metabolic consequences than pulsatile patterns