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The early separation of the cumulative incidence functions reflects the drugs rapid mechanism of action, a finding supported by preclinical studies (in rodents and vervet monkeys) and human data showing immediate changes in craving and substance use after administration of a GLP-1 receptor agonist.3116667 Our treatment adherence analyses are consistent with this, showing a constant relative effect that is established early and sustained during adherence (eg, risk ratio 0.76 for protocol 1 at the end of year 1, 2, and 3)

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