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4,47,50 Furthermore, it is quite clear from earlier studies by Lobie and colleagues that GH has differential effects depending on whether the source of GH is pulsatile secretion from the pituitary or secretion from cancer cells or other cells in the tumor microenvironment

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This could be due to a Zn-induced inhibition of phosphatase activity, leading to Mitogen-activated protein kinase (MAPK) and activator protein-1 (AP-1) activation, resulting in the enhanced IL-8 expression [140]

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