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These include 9 key processes Loss of cholesterol efflux capacity from macrophages Reduced ability to inhibit LDL oxidation Decreased vasodilation through reduced NO production in endothelial cells Reduced ability to inhibit monocyte chemotactic activity Loss of the ability to metabolize hydroperoxides on erythrocyte membranes Reduced ability to suppress TNF-induced NF-B activation and adhesion molecule expression Loss of anti-apoptotic capacity in endothelial cells Decreased capacity to block TNF-induced NADPH oxidase activity and superoxide production Suppression of cytokine inhibition in activated inflammatory cells

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Moreover, Jakob Hasselstrm Jensen et al