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The rate-limiting enzyme in this pathway is Indoleamine 2,3-dioxygenase 1 (IDO-1), which is upregulated by pro-inflammatory agents such as interferon- (IFN-) and tumor necrosis factor-alpha (TNF-), interleukin-1 (IL-1), interleukin-12 (IL-12), all cytokines that are released during inflammatory responses (Yang et al., 2024)

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When combined with reduced saliva production, this puts the teeth at even greater risk of damage

To get the facts about these diabetes-turned-obesity meds, we asked experts to share how GLP-1s lead to weight loss, what side effects to keep an eye on, and how to know if your weight-loss journey could benefit from adding medication