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5-Amino-1MQ was identified as a potent NNMT inhibitor in work published by the Bhatt Lab and collaborators, with subsequent preclinical studies demonstrating that NNMT inhibition in diet-induced obese mice reduced body weight, decreased adipose tissue mass, and improved metabolic parameters including insulin sensitivity and plasma lipids

Notably, deficiencies of riboflavin, folate, iron and other nutrients can also cause this condition, as can sunny, dry or windy weather and other external factors ( Summary Sore lips with cracks in the corners of your mouth can be a sign of B6 deficiency

PMID 33204422