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doi: 10.1080/1028415X.2020.1764292 215

The microbiome-gut-brain content axis consists of three bidirectional, biochemical, signaling pathways between the gut and the brain, and these three pathways include the nervous, endocrine, and immune pathways (198)

Furthermore, iron accumulation is even higher in the substantia nigra in Parkinsons disease (PD) and in anatomical regions affected by -amyloid plaques and tau protein loading in Alzheimers disease (AD) suggesting iron overload as a key factor in the pathogenesis of common neurodegenerative diseases [80, 81]