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After a B12 shot, blood levels rise well above the desired range (150-700 pmol/L in most places), and stay high for a while

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Because IGF-1 is normally found at low levels in MetS and T2D, maybe because of insulin cessation to inhibit IGFBP-1 production by the liver and because of decreased liver IGF-1 secretion by insulin stimulation, as insulin resistance prevails in the liver