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The LRRK2 mutations impair synaptic vesicle endocytosis, leading to alterations of DA metabolism and DA-mediated toxic effects in dopaminergic neurons derived from iPSCs generated from reprogrammed PD patient fibroblasts carrying LRRK2 mutations [132]

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Correct measured deficiencies Protein and amino-acid adequacy Zinc, manganese, magnesium and selenium when deficient Vitamin D, B12 and other documented deficiencies Copper correction according to copper, zinc and ceruloplasmin 3