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Keywords: riboflavin, human health, coenzyme, metabolic function, therapeutical potential 1

We focus on endocrine regulation of ECM dynamics, the crosstalk among hepatic stellate cells (HSCs), immune cells, and the fibrotic niche, and integrin-mediated mechanotransduction pathways linking matrix stiffness to pro-fibrotic gene expression ( 2 Thyroid dysfunction and MAFLD: pathophysiological links MAFLD, previously referred to as nonalcoholic fatty liver disease (NAFLD), is a redefined entity that encompasses hepatic steatosis in conjunction with metabolic dysregulationsuch as obesity, type 2 diabetes mellitus, or other metabolic risk factors ( 2.1 Thyroid hormones and receptors in MAFLD: metabolic and fibrotic regulation Building upon the mechanistic links between hypothyroidism and MAFLD, this section highlights the roles of THs and their nuclear receptors in regulating hepatic metabolism and fibrogenesis

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However, the natural product T2 , with a replacement of the sulfur atom of T1 by an oxygen atom, shows 713-fold decrease in the inhibitory ability (IC 50 = 378.11 M)