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The overall increased risk remains minimal when doses are titrated gradually as recommended

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The data showed that once-weekly 1 mg doses of semaglutide were shown to reduce the likelihood of a first-time heart failure event, urgent visits or hospitalizations due to heart failure, or cardiovascular death

Three reviewers (RZ, QH, PS) graded the strength of evidence as high, moderate, low and very low degree, following five assessment criteria which were risk of bias, inconsistency, indirectness, publication bias, and imprecision