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Intranasal administration, though less studied with Dihexa specifically, would theoretically provide the most direct CNS delivery with minimal systemic exposurepotentially requiring even less frequent dosing to maintain effective brain tissue concentrations

Supplementation with a multivitamin-mineral preparation may be considered under clinician or dietitian guidance during periods of rapid weight loss, particularly when dietary intake is limited, though this should not replace a varied, nutrient-dense diet