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In vivo experiments in tail-suspended mouse models confirmed that LASSS treatment significantly reduces HGF nitration and preserves muscle repair signals, offering a promising therapeutic target for sarcopenia, age-related atrophy, and prolonged disuse

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J Neurosci 31(17):65876594 Hansen HH, Barkholt P, Fabricius K, Jelsing J, Terwel D, Pyke C, Knudsen LB, Vrang N (2016) The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy

LIR was found to stimulate the thermogenesis of brown adipose tissue and the browning of adipose cells, independent of the intake of nutrients