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Pickart's research group went on to demonstrate that the Cu(II) coordination geometry an N3O distorted square-planar pyramid was the operative pharmacophore: free GHK without copper retains only a fraction of the wound-healing and gene-modulating activity of the chelate.[1][2] Research framework Within the matrix-remodeling and tissue-repair peptide research domain, GHK-Cu is most directly compared with BPC-157 for parallel cytoprotection and angiogenic signaling, with TB-500 for actin-cytoskeleton-mediated wound dynamics, and with Thymosin alpha-1 for companion immunoregulatory crosstalk
[ Links ] Machado Rocha FC, Stfano SC, De Cssia Haiek R, Rosa Oliveira LM, Da Silveira D (2008) Therapeutic use of Cannabis sativa on chemotherapy-induced nausea and vomiting among cancer patients: systematic review and meta-analysis
2014;146(1):96-109.e1
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