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Mechanisms controlling pancreatic islet cell function in insulin secretion

As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. NNMT is responsible for converting nicotinamide (NA) into 1-methylnicotinamide (1-MNA), which takes it out of the NAD salvage pathway (see the diagram below)

Future studies should investigate the role of the two mechanisms, as well as assess the duration of therapeutic efficacy and an optimal treatment dosage

Where do our bodies get vitamin B12