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Calcineurin inhibitors, such as tacrolimus and cyclosporine, have remission rates of 6387% in azathioprine-intolerant patients and 4153% in non-responders [111,112,113]

The idea that a lipid-rich substance has the potential to reverse the effects of certain drugs began in the 1960s, when several animal experiments demonstrated that intravenous administration of an oil emulsion decreased the duration of action of thiopental or decreased the free fraction of chlorpromazine in blood

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