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It was first reported by Sawyer, Hruby, Hadley and colleagues in the Proceedings of the National Academy of Sciences in 1980, and it departs from native human alpha-MSH at only two of thirteen positions: norleucine replaces the oxidation-prone methionine at position 4, and the phenylalanine at position 7 is inverted to its D-enantiomer

In the following excerpt, Derek talks to David Ricks about the genesis and evolution of GLP-1 drugs

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But after about six months on the drug, she was 50 pounds lighter