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While these findings have generated significant interest, human studies remain limited, making it difficult to draw definitive conclusions about its clinical benefits

After the passage through the mucus, paracellular and transcellular transport and extracellular diffusion can mediate the access to the CNS, which can occur in the epithelium of respiratory and olfactory mucosa (Lochhead and Davis, 2019)

In vitro experiments on lung cancer cells revealed that L-asparaginase treatment significantly induced autophagy activation in A549 cells, leading to their apoptosis (108)

AS: Formal analysis, Investigation, Methodology, Validation, Writing original draft