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4.3.1 Oxidative stress responses in AP In the pathogenesis of AP, the generation of ROS, and the disruption of redox homeostasis are pivotal factors

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In 2024 alone, it surpassed lung cancer as the most diagnosed cancer type worldwide, with over 2.3 million new cases every year ( BRCA1 frequency and are more prone to develop TNBC with poor clinical outcomes compared to women of European origin ( The incidence rate of breast cancer also depends on age, as women in the USA and Canada on average develop it between 60 and 70 years, whereas women in countries of Asian origin, such as Japan and South Korea, develop it between 40 and 50 years ( Beyond race and ethnicity, reproductive characteristics play another major role in deciding the onset of breast cancer in countries such as Brazil, Egypt, and Nigeria, where women develop breast cancer with aggressive tumor biology and poor prognosis in their premenopausal state ( The development of breast cancer is associated with several factors, such as genetic predisposition, hormonal exposure, lifestyle changes, and environmental factors ( Figure 1 .)