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In OA models induced by interleukin-1 beta (IL-1) and ferric ammonium citrate (FAC), hallmark ferroptosis markers such as glutathione peroxidase 4 (GPX4) and solute carrier family seven member 11 (SLC7A11) exhibit significant downregulation, whereas expression levels of the tumor suppressor gene p53 and acyl-CoA synthetase long-chain family member 4 (ACSL4) are elevated (Yao et al., 2021)

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Micro-dosing strategies attempt to modulate signaling intensity rather than deliver large bolus quantities, a concept increasingly discussed in experimental use of the wolverine stack peptide framework