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"I think the big companies, Novo Nordisk and Eli Lilly, and even other companies were trying from the beginning to develop medicines based on GLP-1

Evidence grade Moderate (8/10) The GLP-1 semaglutide (#Ozempic) failed to improve mood and executive functioning in this, the first RCT of a GLP-1 for major #depression: sciencedirect.com/science/articl Weight loss was significant (all subjects were overweight/obese)

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This approach is entirely off-label and unvalidated, but it reflects the creative problem-solving that patients pursue when conventional options fail