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As of December 2025, anyone considering compounded tirzepatide should: Verify the current FDA shortage status for tirzepatide through the FDA drug shortage database Confirm compounded tirzepatide remains legally available under the current FDA enforcement policy Understand that compounding availability may be materially restricted and is subject to change based on FDA determinations about commercial supply adequacy Review the most current FDA guidance on compounded medications, as policies affecting availability can change rapidly According to FDA communications, the agency has expressed ongoing concerns about the safety and quality of compounded tirzepatide products, including risks of dosing errors, contamination, and adverse events that may be underreported compared to FDA-approved products

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