how long to stay on glp 1 Should You Semaglutide or Tirzepatide for Long-Term Weight Loss? YOUR FIRST 30 DAYS ON

Balica M, Bostrom K, Shin V, Tillisch K, Demer LL

Semaglutide medications work by activating the GLP-1 receptor alone, while tirzepatide medications activate both the GLP-1 receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor, creating what is commonly described as a dual incretin mechanism

7 8 This is the most decision-relevant human-adjacent evidence for a skin goal

Clinicians should exercise caution in patients with a history of pancreatitis or gastroparesis, inflammatory bowel disease, other gut motility disorders, medullary thyroid carcinoma, or Multiple Endocrine Neoplasia syndrome type 2, and pause therapy when clinically indicated, such as before anesthesia