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By supporting the activity of gamma-aminobutyric acid (GABA), a key neurotransmitter, magnesium reduces overactivity in the brain and promotes a sense of calm, making it easier to fall asleep

All patients received a standard lifestyle intervention which included instruction on a reduced-calorie diet (approximately 500 kcal/day deficit) and increased physical activity counseling (recommended minimum of 150 min/week) that began with the first dose of ZEPBOUND, during the lead-in period, and continued throughout the trial

Safety Considerations and Who Should Discuss GLP-1s With Their Provider GLP-1 medications carry side effects including nausea, vomiting, constipation, and rare pancreatitis

6.2.1 Dysbiosis and neuroinflammation I/R injury induces significant changes in the composition of the gut microbiota, a condition known as dysbiosis