In addition to modulating vascular tone by activating signaling events in the underlying vascular smooth muscle cells, endothelial cell-derived NO reduces the production of pro-inflammatory cytokines, reduces leukocyte and monocyte recruitment and adhesion to the endothelium, inhibits the proliferation of vascular smooth muscle cells, inhibits apoptosis, and attenuates platelet aggregation
The modelling approach we have utilised in this study facilitates the exploration of potential toxicity based on a compounds physicochemical properties, in this instance the reduction potential
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Castilla J, Martnez-Baz I, Martnez-Artola V, Reina G, Pozo F, Garca Cenoz M, et al
