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What the Clinical Evidence Says About Stopping GLP-1 Medications The STEP 4 trial tracked weight outcomes after semaglutide discontinuation and found that participants regained an average of 12-15 pounds within 30 weeks of stopping the medication
Exploration of New Targets Although GLP-1 drugs have achieved tremendous success in weight loss, their limitations are becoming increasingly apparent, such as weight rebound after treatment, muscle loss alongside fat loss, and suboptimal response rates in some patients
SEMA was shown to be the most effective of its category in terms of meaningful weight reduction as it can penetrate certain areas in the central nervous system that are critical for hunger and appetite control and are not protected by the blood-brain barrier, regulating key appetite-modulating relay areas [70, 73]
[3] Clinical trials showed dose-dependent weight reduction, with higher doses producing greater average weight loss
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