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For patients whose primary goal is fat loss and body composition improvement: Ipamorelin may be preferred due to its selective GH stimulation without cortisol elevation Cortisol is directly antagonistic to fat loss, particularly visceral fat The clean GH pulse from ipamorelin supports lipolysis without metabolic interference Sermorelin also supports fat metabolism through sustained GH improvement The best approach depends on individual factors including baseline hormone levels, cortisol status, and treatment goals

HUBERMAN: Now, in principle, any discussion about peptides could be enormously vast, and that's because there are so many different kinds of peptides, and by the way, I will explain what a peptide is in just a few moments

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Mol Cell Endocrinol (2016) 436:2409