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Furthermore, our results can be generalised mostly to individuals with type 2 diabetes who are already on metformin-based background therapy, given that drug-naive individuals were recruited only in one study [22]

That same clinical evidence base also shows that these medications don't work equally for every patient, that gastrointestinal side effects are common especially during dose escalation, and that weight tends to return when medication is discontinued without sustained lifestyle changes

Semaglutide injection activates GLP-1 receptors in your brain and gut within hours of administration, but the subjective sensation of appetite suppression usually emerges within 37 days of your first dose