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The intricate coordination of enzymatic steps, transport mechanisms, and regulatory pathways underscores the critical importance of heme degradation and bilirubin formation in maintaining metabolic homeostasis and preventing disease

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238,242 Isocitrate dehydrogenase 3 (IDH3), a pivotal rate-limiting enzyme in the TCA cycle, is downregulated, leading to oxidative phosphorylation uncoupling and lactate accumulation in the brains of AD patients and AD transgenic mice

Several studies reported that tumors, including pancreatic ductal adenocarcinoma (PDAC) and esophageal cancer, inherently have low glutamine levels compared to benign adjacent tissues or other normal tissues [36,37,38]