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The cumulative incidence of NAION over 36 months was 6.7% for the semaglutide group versus 0.8% for the non-GLP-1 RA group

The global prevalence of 537 million affected in the age group of 2079 years in 2021 will rise to 783 million in 2045, with the lowest increase in incidence in Europe (13%) and the highest in the African countries south of the Sahara (134%) (15)

Moreover, oral semaglutide has also shown promising results in patients with obesity, as demonstrated by the OASIS-1 trial, 18 yet no previous study has explored the cost-effectiveness of oral semaglutide as an antiobesity treatment

For the latter, the drugs do two things