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For many patients, these symptoms appear within the first few months of taking a GLP-1 medication, precisely when weight loss and bile concentration are at their highest

doi:10.1016/j.drugalcdep.2018.06.004 Suffoletto B, Zeigler A

When M1 MEVs are introduced into the tumor microenvironment, they influence the surrounding M2 macrophages to adopt a more pro-inflammatory, tumor-fighting state by increasing the secretion of cytokines such as TNF- and upregulating pro-inflammatory markers like CXCL8

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