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administration options 1,2 important administration instructions 1 See the Instructions for Use for more detailed instructions on the preparation and administration of DUPIXENT Patients and/or caregivers should read the Instructions for Use prior to injecting Instruct patients and/or caregivers to administer the subcutaneous injection into the thigh or abdomen, except for the 2 inches (5 cm) around the navel The upper arm can also be used if a caregiver administers the injection It is important to rotate the injection site with each injection

Anti-Inflammatory & Cytoprotective Action Reduces levels of pro-inflammatory cytokines (TNF-, IL-6) and oxidative stress markers, supporting recovery across multiple tissue types

Many POTS patients claim heat intolerance and this may be mediated by unopposed glutamate [64]