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however, it is unlikely to be a sole action of glutamate excitotoxicity (85)

During the acute phase of sepsis, glutathione synthesis is enhanced in the liver and other tissues, a process regulated by multiple factors, including a decreased reduced/oxidized glutathione ratio, reactive oxygen and nitrogen species, proinflammatory cytokines, heat shock proteins, and physical inactivity

Lewis AD, Hayes JD, Wolf CR

Another clinical study clarified that adding RSV (100 mg/day, P.O for 2 months) better improved left ventricular ejection fraction and left ventricular diastolic function in patients with CHD compared with standard treatment alone [199]