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Because of its slow action and high post-treatment recurrence rate, ursodeoxycholic acid is not widely recommended, and its use is generally reserved for those who cannot undergo surgery (Portincasa 2012
420,421 Another limitation of CPPs is their limited clinical efficacy, often requiring high concentrations and doses to achieve a therapeutic effect, which can cause significant toxicity and side effects, hindering the development of clinical applications
Gross analysis of femurs at 3 and 12 weeks of age showed no significant difference in overall length (Figure 2b and 2c) or organization of the growth plate (Figure 2d) in CartIR / mice compared to controls
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