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Newborns are often exposed to oxygen therapies, have low antioxidant defenses despite high levels of toxic radicals, and are more susceptible to infections, especially if born prematurely 99

With the progression of ALS there may be an additional decrease in GABA concentration due to a decrease in glutamine released from the glutamate/glutamine neurotransmitter cycle being required for net GABA synthesis (Figure 1C shows the additional decrease in cellular GABA predicted with further progression of ALS