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Acylated GLP-1RAs, like liraglutide and semaglutide, heve limited direct BBB penetration but still reach critical areas such as the arcuate nucleus (ARH) through indirect pathways [125]

A nuance worth stating plainly: the strict "oral = gut only, injection = everything else" dichotomy is a simplification

CagriSema also produced significant improvements in systolic blood pressure (a 10.9 mmHg reduction), along with improvements in lipids and inflammatory markers