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10.1038/nprot.2014.085 20 HertzL.ChenY
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Several physiological mechanisms explain why rapid weight loss promotes gallstone formation: Altered bile composition : During significant caloric restriction and rapid fat mobilisation, the liver secretes increased amounts of cholesterol into bile whilst bile salt secretion remains relatively constant, creating cholesterol-supersaturated bile Reduced gallbladder motility : Decreased food intake, particularly reduced dietary fat, means less frequent gallbladder contraction and emptying, allowing bile to stagnate and cholesterol crystals to form Increased cholesterol mobilisation : As adipose tissue is broken down, cholesterol is released into the circulation and subsequently excreted via bile Studies of patients undergoing bariatric surgeryanother intervention causing rapid weight losshave demonstrated gallstone formation rates of 3050% within the first year post-operatively when prophylactic measures are not employed, though many of these stones remain asymptomatic
A 2022 analysis of endometrial gene expression by age revealed altered expression of genes related to cilia motility and epithelial cell proliferation in women over 35 years (Vitagliano et al., 2023), suggesting the role of a non-ovarian factor in dictating pregnancy outcomes in older women
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