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This study (STEP-1 trial) demonstrated that participants using semaglutide lost a significant amount of weight, with approximately 39% of the weight loss attributed to lean mass , raising concerns about muscle preservation during GLP-1-induced weight loss

For patients with pre-existing pancreatic conditions requiring prescribed pancreatic enzyme replacement therapy, continuing this treatment alongside Ozempic is generally appropriate, though medical supervision remains important to ensure optimal management of both conditions

As retatrutide has not yet been approved, there is no official MHRA-approved Summary of Product Characteristics (SmPC) available to confirm these figures definitively, and all pharmacokinetic estimates should be regarded as preliminary

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