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Our study was in line with the previous study that upregulation of FTH could alleviate cisplatin induced HK2 cell injury through anti-ferroptosis (Hu et al., 2020)

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The enzyme aldose reductase which produces intermediate sorbitol is a NADPH requiring enzyme with a high Km for glucose [7], thus elevated intracellular glucose concentrations and an adequate supply of NADPH leads to a significant increase in the amount of sorbitol

Whatever autoimmune disease may be present, improving the balance of gut bacteria to strengthen the intestinal lining may help keep autoimmunity at bay