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The most commonly advertised contraindication is a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2
The iron-overloaded environment of follicular fluid could not only inhibit the expression of GPX4 and its upstream regulatory target GSH but also cause the high expression of NCOA4 in granulosa cells
Yet, despite its relevance, the relationship of betaine and choline to homocysteine metabolism has been only lightly investigated in humans, essentially because the choline content of foods could not be accurately measured until fairly recently
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