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9 The original Diabetes Prevention Program (DPP) trial, published in 2002, showed that intensive lifestyle change (a 7% weight loss target plus 150 minutes of physical activity per week) reduced the incidence of type 2 diabetes by 58% over 3 years

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This work further highlights how physiologically relevant in vitro systems are becoming a mechanistic backbone for predicting oral bioavailability, improving translational relevance, and supporting the development of next-generation therapeutics

Small-breed dogs often get discussed in the context of degenerative valve disease as they age, while certain large breeds show up more often in discussions around dilated cardiomyopathy