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Nicotinamide N-methyltransferase as a potential therapeutic target in metabolic and related diseases

This is uncommon but occasionally reported anecdotally, particularly at very high doses

extreme caloric restriction may exacerbate menstrual irregularities Micronutrient optimization: Maintain adequate iron intake, particularly if experiencing heavier menstrual bleeding Contraceptive considerations: Discuss alternative contraceptive methods with your provider, as tirzepatide may affect oral contraceptive absorption For women with pre-existing menstrual irregularities or PCOS, tirzepatide treatment may ultimately improve cycle regularity as metabolic parameters normalize

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